Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.50 |
| ▸ | CTSG | P08311 | 1/20 | 0.50 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.50 |
| ▸ | CMA1 | P23946 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1765747 | 0.94 | ALDH1A1 (0.53) | ALDH1A1PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL2646805 | 0.84 | PRSS1 (0.66) | ALDH1A1PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL19609296 | 0.83 | NPC1 (0.56) | ALDH1A1MAPTSMN1; SMN2LMNANPC1 | |
| SCHEMBL2650710 | 0.83 | MAPT (0.54) | ALDH1A1PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL10309655 | 0.81 | EPHX2 (0.52) | ALDH1A1PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL2646800 | 0.81 | CA1 (0.58) | ALDH1A1PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL2646881 | 0.81 | CA1 (0.58) | ALDH1A1PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL2280467 | 0.79 | HPGD (0.62) | ALDH1A1MAPTSMN1; SMN2EPHX2NR1H4 | |
| SCHEMBL2281194 | 0.79 | EPHX2 (0.56) | ALDH1A1SMN1; SMN2EPHX2NR1H4LMNA | |
| SCHEMBL12989840 | 0.79 | EPHX2 (0.52) | ALDH1A1PRSS1CTSGCTRB1CMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |