Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.58 |
| ▸ | CA2 | P00918 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.48 |
| ▸ | NME4 | O00746 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.48 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | GCDH | Q92947 | 1/20 | 0.48 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2646881 | 1.00 | CA1 (0.58) | CA1CA2MAPK1ALDH1A1EPHX2 | |
| SCHEMBL16688444 | 0.89 | MAPK1 (0.76) | CA1CA2MAPK1ALDH1A1EPHX2 | |
| SCHEMBL9717434 | 0.87 | MAPK1 (0.71) | CA1CA2MAPK1ALDH1A1SIRT5 | |
| SCHEMBL12989840 | 0.85 | EPHX2 (0.52) | CA1CA2MAPK1ALDH1A1EPHX2 | |
| SCHEMBL2646805 | 0.83 | PRSS1 (0.66) | CA1CA2MAPK1ALDH1A1EPHX2 | |
| SCHEMBL1664008 | 0.82 | POLB (0.53) | CA1CA2MAPK1ALDH1A1EPHX2 | |
| SCHEMBL1765747 | 0.82 | ALDH1A1 (0.53) | ALDH1A1EPHX2NR1H4PRSS1CTSG | |
| SCHEMBL13760114 | 0.82 | CA1 (0.54) | CA1CA2MAPK1EPHX2NR1H4 | |
| SCHEMBL22042366 | 0.81 | MAPK1 (0.51) | MAPK1ALDH1A1EPHX2NR1H4LMNA | |
| SCHEMBL2654472 | 0.81 | UNG (0.56) | CA1CA2MAPK1PRSS1CTSG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005058845-A2 | NOVEL GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2005-06-30 | — | — | WO | disclosed |
| EP-1463715-A1 | NOVEL GLUCAGON ANTAGONISTS | NOVO NORDISK A/S (DK) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003048109-A1 | NOVEL GLUCAGON ANTAGONISTS | NOVO NORDISK A/S (DK) | 2003-06-12 | — | — | WO | disclosed |