Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.45 |
| ▸ | RXRB | P28702 | 3/20 | 0.45 |
| ▸ | RXRG | P48443 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 5/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.34 |
| ▸ | CASR | P41180 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654304 | 0.89 | RXRA (0.47) | RXRARXRBRXRGKIF11PSEN1 | |
| SCHEMBL2651107 | 0.80 | MAOB (0.44) | KIF11PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2652928 | 0.80 | RXRA (0.51) | RXRARXRBRXRGKIF11PSEN1 | |
| SCHEMBL1779625 | 0.79 | RXRA (0.54) | RXRARXRBRXRGKIF11PSEN1 | |
| SCHEMBL2653214 | 0.79 | RXRA (0.48) | RXRARXRBRXRGKIF11MAPT | |
| SCHEMBL2652563 | 0.78 | HTR2A (0.36) | KIF11PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28173593 | 0.77 | PDE2A (0.46) | AKR1C3AKR1C2MC4R | |
| SCHEMBL3230214 | 0.76 | RXRA (0.50) | RXRARXRBRXRGKIF11PSEN1 | |
| SCHEMBL12603784 | 0.75 | RXRA (0.55) | RXRARXRBRXRGKIF11CA12 | |
| SCHEMBL2272131 | 0.73 | RXRA (0.50) | RXRARXRBRXRGKIF11CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |