Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2651107 | 0.83 | MAOB (0.44) | HTR2AHTR2CHTR2BPSEN1PSEN2 | |
| SCHEMBL2656189 | 0.79 | RXRA (0.43) | MAPTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2653589 | 0.78 | RXRA (0.45) | MAPTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2657021 | 0.73 | MAPT (0.39) | MAPTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4608415 | 0.73 | ALDH1A1 (0.41) | PPARAKCNH2TMEM97NPC1ALDH1A1 | |
| SCHEMBL1765105 | 0.71 | KIF11 (0.55) | MAPTKIF11 | |
| SCHEMBL1133428 | 0.70 | MAPT (0.48) | MAPTKIF11 | |
| SCHEMBL2652984 | 0.70 | MAOB (0.46) | HTR2AHTR2CHTR2BPSEN1PSEN2 | |
| SCHEMBL2271994 | 0.69 | PSEN1 (0.48) | PDE2AMAPTPSEN1PSEN2APH1B | |
| SCHEMBL28173593 | 0.69 | PDE2A (0.46) | HTR2AHTR2CHTR2BPDE2AAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |