Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 18/20 | 0.62 |
| ▸ | GABRB3 | P28472 | 18/20 | 0.62 |
| ▸ | GABRA5 | P31644 | 18/20 | 0.62 |
| ▸ | GABRA3 | P34903 | 18/20 | 0.62 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.62 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653199 | 0.85 | GABRG2 (0.63) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2653655 | 0.79 | GABRG2 (0.63) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2654031 | 0.79 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2653163 | 0.78 | GABRG2 (0.52) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2652400 | 0.75 | GABRG2 (0.65) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2652837 | 0.74 | GABRG2 (0.51) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2652309 | 0.73 | GABRG2 (0.46) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2654979 | 0.72 | GABRG2 (0.54) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2650791 | 0.70 | KDM4E (0.43) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2653954 | 0.69 | ABL1 (0.46) | GABRG2GABRB3GABRA5GABRA3GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532120-A1 | PHENYLPYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004014865-A1 | PHENYLPYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2004-02-19 | — | — | WO | disclosed |