Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 16/20 | 0.63 |
| ▸ | GABRB3 | P28472 | 16/20 | 0.63 |
| ▸ | GABRA5 | P31644 | 16/20 | 0.63 |
| ▸ | GABRA3 | P34903 | 16/20 | 0.63 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.63 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654031 | 0.79 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2653652 | 0.79 | GABRG2 (0.62) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2653199 | 0.72 | GABRG2 (0.63) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2651675 | 0.72 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2652400 | 0.66 | GABRG2 (0.65) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2653081 | 0.66 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2651476 | 0.65 | GABRG2 (0.69) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2653163 | 0.65 | GABRG2 (0.52) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2652170 | 0.65 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2652423 | 0.64 | GABRG2 (0.65) | GABRG2GABRB3GABRA5GABRA3GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532120-A1 | PHENYLPYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004014865-A1 | PHENYLPYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2004-02-19 | — | — | WO | disclosed |