Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 7/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27578456 | 0.84 | GCK (0.50) | GCKKCNH2 | |
| SCHEMBL2642192 | 0.84 | GCK (0.50) | GCKKCNH2RAB9ANPC1MAPT | |
| SCHEMBL2653752 | 0.84 | GCK (0.50) | GCKKCNH2RAB9ANPC1MAPT | |
| SCHEMBL2642140 | 0.82 | GCK (0.48) | GCKKCNH2RAB9ANPC1POLB | |
| SCHEMBL2642234 | 0.81 | GCK (0.47) | GCKKCNH2RAB9ANPC1KMT2A | |
| Piragliatin SCHEMBL14423140 | 0.80 | GCK (1.00) | GCKKCNH2FFAR2RAB9ANPC1 | |
| Piragliatin SCHEMBL2642196 | 0.80 | GCK (1.00) | GCKKCNH2FFAR2RAB9ANPC1 | |
| Piragliatin SCHEMBL5878119 | 0.80 | GCK (1.00) | GCKKCNH2FFAR2RAB9ANPC1 | |
| Piragliatin SCHEMBL2642343 | 0.80 | GCK (1.00) | GCKKCNH2FFAR2RAB9ANPC1 | |
| Piragliatin SCHEMBL2655969 | 0.80 | GCK (1.00) | GCKKCNH2FFAR2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101641083-A | The pharmaceutical solid dosage forms that comprises micro-embedded chemical compound in ionic water-insoluble polymers | HOFFMANN LA ROCHE CH | 2010-02-03 | — | — | CN | claimed |
| CN-101641083-A | The pharmaceutical solid dosage forms that comprises micro-embedded chemical compound in ionic water-insoluble polymers | HOFFMANN LA ROCHE CH | 2010-02-03 | — | — | CN | disclosed |
| US-20070254895-A1 | Crystalline solvate of glucokinase activator | CHOI DUK SOON | 2007-11-01 | — | — | US | disclosed |
| WO-2007115967-A1 | CRYSTALLINE ISOPROPANOL SOLVATE OF GLUCOKINASE ACTIVATOR | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254895-A1 | Crystalline solvate of glucokinase activator | GCKR, GCK, PDXK | GCK 2/4885KCNH2 1797/4885FFAR2 353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.