Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.58 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.49 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.49 |
| ▸ | LSS | P48449 | 2/20 | 0.49 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.47 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.47 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL834524 | 0.90 | MAPT (0.66) | MAPTCYP4A11CYP4F2RAB9AMEN1 | |
| SCHEMBL4359850 | 0.86 | MAPT (0.70) | MAPTCYP4A11CYP4F2RAB9APLA2G4B | |
| SCHEMBL4376261 | 0.86 | MAPT (0.70) | MAPTCYP4A11CYP4F2RAB9APLA2G4B | |
| SCHEMBL4361268 | 0.85 | MAPT (0.72) | MAPTCYP4A11CYP4F2RAB9APLA2G4B | |
| SCHEMBL2655200 | 0.85 | PLA2G4B (0.67) | CYP4A11CYP4F2PLA2G4BFFAR1 | |
| SCHEMBL5054312 | 0.84 | MAPT (0.85) | MAPTRAB9APLA2G4BMEN1NPC1 | |
| SCHEMBL7424382 | 0.83 | MAPT (0.64) | MAPTCYP4A11CYP4F2RAB9APLA2G4B | |
| SCHEMBL27525241 | 0.83 | MAPT (0.59) | MAPTCYP4A11CYP4F2RAB9AMEN1 | |
| SCHEMBL2653558 | 0.82 | CYP4A11 (0.56) | MAPTCYP4A11CYP4F2RAB9APLA2G4B | |
| SCHEMBL24684534 | 0.81 | MAPT (0.74) | MAPTRAB9APLA2G4BMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |