Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.56 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.56 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.47 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | CCR6 | P51684 | 1/20 | 0.44 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1796551 | 0.82 | MAPT (0.47) | CYP4A11CYP4F2RAB9ALOXL2L3MBTL1 | |
| SCHEMBL2653776 | 0.82 | MAPT (0.60) | CYP4A11CYP4F2PLA2G4BNPC1RAB9A | |
| SCHEMBL15191795 | 0.81 | MAPT (0.49) | CYP4A11CYP4F2NPC1RAB9ALOXL2 | |
| SCHEMBL17517566 | 0.79 | CYP4A11 (0.58) | CYP4A11CYP4F2RAB9ALOXL2L3MBTL1 | |
| SCHEMBL22438891 | 0.79 | THRA (0.58) | NPC1RAB9AALDH1A1KMT2AMAPT | |
| SCHEMBL1833382 | 0.79 | CYP4A11 (0.52) | CYP4A11CYP4F2LOXL2ALDH1A1LMNA | |
| SCHEMBL10366608 | 0.78 | KMT2A (0.53) | CYP4A11CYP4F2RAB9ALOXL2L3MBTL1 | |
| SCHEMBL3712221 | 0.78 | MAPT (0.49) | CYP4A11CYP4F2NPC1RAB9ALOXL2 | |
| SCHEMBL2654795 | 0.78 | CCR6 (0.45) | CYP4A11CYP4F2NPC1RAB9ACCR6 | |
| SCHEMBL1893005 | 0.77 | CYP4A11 (0.63) | CYP4A11CYP4F2CCR6HKDC1LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |