Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | RARB | P10826 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.44 |
| ▸ | GCG | P01275 | 2/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.44 |
| ▸ | GCGR | P47871 | 7/20 | 0.43 |
| ▸ | ADCY6 | O43306 | 2/20 | 0.43 |
| ▸ | ADCY3 | O60266 | 2/20 | 0.43 |
| ▸ | ADCY9 | O60503 | 2/20 | 0.43 |
| ▸ | ADCY5 | O95622 | 2/20 | 0.43 |
| ▸ | ADCY8 | P40145 | 2/20 | 0.43 |
| ▸ | ADCY7 | P51828 | 2/20 | 0.43 |
| ▸ | ADCY2 | Q08462 | 2/20 | 0.43 |
| ▸ | ADCY1 | Q08828 | 2/20 | 0.43 |
| ▸ | ADCY4 | Q8NFM4 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653408 | 0.90 | RARB (0.49) | NPC1RAB9ASMN1; SMN2RARBS1PR1 | |
| SCHEMBL2654924 | 0.90 | RARB (0.52) | NPC1RAB9ASMN1; SMN2RARBS1PR1 | |
| SCHEMBL2653706 | 0.89 | RARB (0.48) | NPC1RAB9ARARBS1PR1FFAR1 | |
| SCHEMBL2655125 | 0.89 | GCGR (0.49) | NPC1RAB9ARARBS1PR1FFAR1 | |
| SCHEMBL2655236 | 0.88 | GCGR (0.46) | NPC1RAB9ASMN1; SMN2S1PR1GCG | |
| SCHEMBL2653422 | 0.88 | PPARD (0.51) | RARBS1PR1FFAR1S1PR3S1PR5 | |
| SCHEMBL2655131 | 0.87 | GCG (0.44) | NPC1RAB9ASMN1; SMN2GCGGCGR | |
| SCHEMBL2654685 | 0.86 | FFAR4 (0.49) | NPC1RAB9ASMN1; SMN2RARBS1PR1 | |
| SCHEMBL2653686 | 0.85 | GCG (0.47) | NPC1RAB9ASMN1; SMN2GCGGCGR | |
| SCHEMBL2655267 | 0.84 | RXRA (0.55) | NPC1RAB9ASMN1; SMN2S1PR1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | claimed |
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |