Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.48 |
| ▸ | GCGR | P47871 | 10/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | GCG | P01275 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654712 | 0.84 | GCG (0.47) | GCGRGCGHRH3 | |
| SCHEMBL2655295 | 0.82 | FOLH1 (0.44) | GCGRGCGHRH3 | |
| SCHEMBL2655306 | 0.82 | HRH3 (0.43) | GCGRGCGHRH3 | |
| SCHEMBL2654684 | 0.82 | GCGR (0.47) | GCGRGCGHRH3 | |
| SCHEMBL2654700 | 0.81 | MMP12 (0.45) | CD274GCGRHDAC1GCGHRH3 | |
| SCHEMBL2655487 | 0.81 | GCG (0.60) | GCGRGCGHRH3 | |
| SCHEMBL2656081 | 0.81 | GCGR (0.55) | GCGR | |
| SCHEMBL1765672 | 0.77 | GCG (0.67) | CD274GCGRGCG | |
| SCHEMBL2653809 | 0.77 | MCHR1 (0.37) | GCGRGCGHRH3 | |
| SCHEMBL2653361 | 0.75 | NPC1 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | claimed |