Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCG | P01275 | 3/20 | 0.60 |
| ▸ | PTAFR | P25105 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | GCGR | P47871 | 8/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.38 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.38 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.38 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654712 | 0.87 | GCG (0.47) | GCGHRH3GCGRNPC1RAB9A | |
| SCHEMBL2655306 | 0.86 | HRH3 (0.43) | GCGHRH3GCGRNPC1RAB9A | |
| SCHEMBL2654684 | 0.86 | GCGR (0.47) | GCGHRH3GCGRADCY6ADCY3 | |
| SCHEMBL2654700 | 0.85 | MMP12 (0.45) | GCGHRH3GCGRNPC1RAB9A | |
| SCHEMBL2653257 | 0.83 | GCG (0.42) | GCGHRH3GCGRNPC1RAB9A | |
| SCHEMBL2654574 | 0.83 | GCG (0.57) | GCGPTAFRHRH3PSEN1PSEN2 | |
| SCHEMBL2656081 | 0.83 | GCGR (0.55) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL2655295 | 0.83 | FOLH1 (0.44) | GCGHRH3GCGRNPC1RAB9A | |
| SCHEMBL2654473 | 0.82 | GCGR (0.54) | GCGGCGRNPC1RAB9AADCY6 | |
| SCHEMBL2653963 | 0.81 | CD274 (0.48) | GCGHRH3GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |