⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL124734 | 0.80 | — | — | |
| SCHEMBL4006099 | 0.80 | GAA (0.70) | — | |
| Malonic Acid Diethyl Ester SCHEMBL3823348 | 0.80 | GAA (0.79) | — | |
| SCHEMBL6894888 | 0.79 | CYP1A2 (0.54) | — | |
| Malonic Acid Diethyl Ester SCHEMBL8636 | 0.79 | GAA (1.00) | — | |
| Malonic Acid Diethyl Ester SCHEMBL1330550 | 0.79 | GAA (1.00) | — | |
| Malonic Acid Diethyl Ester SCHEMBL1864301 | 0.79 | GAA (1.00) | — | |
| Malonic Acid Diethyl Ester SCHEMBL1331824 | 0.79 | GAA (1.00) | — | |
| Malonic Acid Diethyl Ester SCHEMBL1331187 | 0.79 | GAA (1.00) | — | |
| SCHEMBL9270094 | 0.78 | GAA (0.67) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 130 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1126833-A4 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES INC (US) | 2004-09-08 | — | — | EP | claimed |
| EP-1126833-A2 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2001-08-29 | — | — | EP | claimed |
| WO-2000025768-A1 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2000-05-11 | — | — | WO | claimed |
| US-12527776-B2 | Treatment of ciliopathies using inhibitors of glucosylceramide synthase (GCS) | GENZYME CORPORATION (US) | 2026-01-20 | — | — | US | disclosed |
| US-20250290137-A1 | SUBSTITUTED COUMARIN DYES AND USES AS FLUORESCENT LABELS | ILLUMINA CAMBRIDGE LIMITED (GB) | 2025-09-18 | — | — | US | disclosed |
| US-12351871-B2 | Substituted coumarin dyes and uses as fluorescent labels | ILLUMINA CAMBRIDGE LIMITED (GB) | 2025-07-08 | — | — | US | disclosed |
| EP-3920912-B1 | TREATMENT OF CILIOPATHIES USING INHIBITORS OF GLUCOSYLCERAMIDE SYNTHASE (GCS) | GENZYME CORP (US) | 2025-06-11 | — | — | EP | disclosed |
| EP-4559918-A2 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | Genzyme Corporation (US) | 2025-05-28 | — | — | EP | disclosed |
| EP-3673906-B1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GENZYME CORP (US) | 2025-05-14 | — | — | EP | disclosed |
| US-12083115-B2 | Methods for treating neurological symptoms associated with lysosomal storage diseases | GENZYME CORPORATION (US) | 2024-09-10 | — | — | US | disclosed |
| US-20240271209-A1 | SUBSTITUTED COUMARIN DYES AND USES AS FLUORESCENT LABELS | ILLUMINA CAMBRIDGE LIMITED (GB) | 2024-08-15 | — | — | US | disclosed |
| EP-0123024-A2 | 7-Acylamino-3-vinylcephalosporanic acid derivatives, processes for their preparation, pharmaceutical compositions containing them; their starting compounds and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-10-31 | — | — | EP | disclosed |
| US-4423213-A | ANTIBIOTIC | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-12-27 | — | — | US | disclosed |
| US-4409214-A | Including cefixime; antibiotics | FUJISAWA PHARMACEUTICAL, CO., LTD. (JP) | 1983-10-11 | — | — | US | disclosed |
| US-4379791-A | 4-(Substituted thiazolyl)-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase | MERCK & CO., INC. (US) | 1983-04-12 | — | — | US | disclosed |
| EP-0025232-B1 | 4-(SUBSTITUTED THIAZOLYL)-3-HYDROXY-3-PYRROLINE-2,5-DIONE COMPOUNDS, PROCESSES FOR PREPARING AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | MERCK & CO. INC. (US) | 1983-01-19 | — | — | EP | disclosed |
| US-4298743-A | TREATMENT AND PREVENTION OF CALCIUM OXALATE RENAL LITHIASIS | MERCK & CO., INC. (US) | 1981-11-03 | — | — | US | disclosed |
| EP-0030630-A2 | 7-Acylamino-3-vinylcephalosporanic acid derivatives, processes for their preparation, pharmaceutical compositions containing them; their starting compounds and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-06-24 | — | — | EP | disclosed |
| EP-0025232-A1 | 4-(Substituted thiazolyl)-3-hydroxy-3-pyrroline-2,5-dione compounds, processes for preparing and a pharmaceutical composition comprising the same | MERCK & CO. INC. (US) | 1981-03-18 | — | — | EP | disclosed |
| US-3985772-A | 3-Amidinocoumarin dyes | BASF AKTIENGESELLSCHAFT (DT) | 1976-10-12 | — | — | US | disclosed |