Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2844080 | 0.80 | MEN1 (0.50) | MEN1KMT2AALDH1A1TDP1HSD17B10 | |
| SCHEMBL12790156 | 0.79 | RORC (0.45) | MEN1HSD17B10TMIGD3ADORA1SMN1; SMN2 | |
| SCHEMBL696137 | 0.79 | MEN1 (0.51) | MEN1KMT2AALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL7382979 | 0.77 | ALDH1A1 (0.50) | MEN1KMT2AALDH1A1TDP1HSD17B10 | |
| SCHEMBL577947 | 0.77 | TMIGD3 (0.47) | MEN1KMT2AALDH1A1HSD17B10ALOX15 | |
| SCHEMBL25309164 | 0.76 | MEN1 (0.49) | MEN1KMT2AALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL2654211 | 0.76 | KMT2A (0.49) | MEN1KMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL18722146 | 0.76 | MEN1 (0.56) | MEN1KMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL11199790 | 0.76 | MEN1 (0.49) | MEN1KMT2AALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL3361917 | 0.75 | RORC (0.46) | MEN1KMT2AALDH1A1HSD17B10TMIGD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003018546-A2 | TRICYCLIC PYRIDIN-2-ONE ANALOGUES AS LIGANDS FOR GABA-A RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2003-03-06 | — | — | WO | disclosed |