Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.60 |
| ▸ | RXRB | P28702 | 3/20 | 0.60 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.60 |
| ▸ | RARB | P10826 | 2/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.46 |
| ▸ | BCL2 | P10415 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PTGES | O14684 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
| ▸ | RARG | P13631 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2661951 | 0.87 | RXRA (0.47) | RXRARXRBNR4A2NR1H4SRD5A2 | |
| SCHEMBL2655270 | 0.85 | GCGR (0.53) | NR1H4EPHX2 | |
| SCHEMBL2655054 | 0.85 | GCGR (0.54) | RXRARXRBNR4A2NR1H4EPHX2 | |
| SCHEMBL2655312 | 0.85 | GCGR (0.54) | RXRARXRBNR4A2NR1H4EPHX2 | |
| SCHEMBL2653886 | 0.85 | GCGR (0.54) | RXRARXRBNR4A2NR1H4EPHX2 | |
| Lifibrol SCHEMBL9484778 | 0.84 | NR4A2 (0.64) | RXRARXRBNR4A2RARBNR1H4 | |
| Lifibrol SCHEMBL140583 | 0.84 | NR4A2 (0.64) | RXRARXRBNR4A2RARBNR1H4 | |
| Lifibrol SCHEMBL9478310 | 0.84 | NR4A2 (0.64) | RXRARXRBNR4A2RARBNR1H4 | |
| SCHEMBL2657119 | 0.82 | NR1H4 (0.47) | NR1H4EPHX2 | |
| SCHEMBL2655396 | 0.82 | NR1H4 (0.46) | NR1H4EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |