Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GCGR | P47871 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | ESRRG | P62508 | 3/20 | 0.41 |
| ▸ | ESRRB | O95718 | 1/20 | 0.41 |
| ▸ | GIPR | P48546 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655312 | 0.91 | GCGR (0.54) | NR1H4EPHX2MAPTLMNANPC1 | |
| SCHEMBL2655054 | 0.91 | GCGR (0.54) | NR1H4EPHX2MAPTLMNANPC1 | |
| SCHEMBL2653886 | 0.91 | GCGR (0.54) | NR1H4EPHX2MAPTLMNANPC1 | |
| SCHEMBL2657119 | 0.84 | NR1H4 (0.47) | NR1H4EPHX2NPC1RAB9AMEN1 | |
| SCHEMBL2655270 | 0.83 | GCGR (0.53) | NR1H4EPHX2NPC1RAB9AL3MBTL1 | |
| SCHEMBL2654483 | 0.82 | RXRA (0.60) | NR1H4EPHX2 | |
| SCHEMBL2655101 | 0.81 | ESRRG (0.49) | NR1H4EPHX2NPC1RAB9AMEN1 | |
| SCHEMBL2654353 | 0.79 | NR1H4 (0.54) | NR1H4EPHX2NPC1RAB9AL3MBTL1 | |
| SCHEMBL2653634 | 0.76 | MEN1 (0.49) | EPHX2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL2662283 | 0.76 | MEN1 (0.46) | MEN1KMT2AGCGRCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |