Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 7/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654708 | 1.00 | HSP90AA1 (0.53) | HSP90AA1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL2655517 | 0.99 | HSP90AA1 (0.54) | HSP90AA1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL2653059 | 0.90 | NPC1 (0.53) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL2661669 | 0.90 | NPC1 (0.62) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL2652991 | 0.87 | NPC1 (0.53) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL2655192 | 0.86 | NPC1 (0.60) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL2652925 | 0.86 | NPC1 (0.49) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL2655457 | 0.86 | NPC1 (0.44) | HSP90AA1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL2654356 | 0.85 | NPC1 (0.53) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL2653784 | 0.85 | NPC1 (0.53) | NPC1RAB9AKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |