Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.49 |
| ▸ | RAB9A | P51151 | 8/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656440 | 0.89 | S1PR1 (0.56) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL2661669 | 0.87 | NPC1 (0.62) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL2653059 | 0.87 | NPC1 (0.53) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL2654708 | 0.86 | HSP90AA1 (0.53) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL2654532 | 0.86 | HSP90AA1 (0.53) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL2655517 | 0.85 | HSP90AA1 (0.54) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL2652991 | 0.84 | NPC1 (0.53) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL2655192 | 0.83 | NPC1 (0.60) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL2654356 | 0.82 | NPC1 (0.53) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL2653784 | 0.82 | NPC1 (0.53) | NPC1RAB9AMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |