Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | FABP2 | P12104 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | ESRRG | P62508 | 2/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ESRRB | O95718 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654449 | 0.85 | CYP4A11 (0.40) | SMN1; SMN2ALDH1A1MAPTGAARAB9A | |
| SCHEMBL2654945 | 0.82 | RXRA (0.38) | MEN1KMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2654812 | 0.81 | GCGR (0.51) | MEN1KMT2AESRRGMAPTRAB9A | |
| SCHEMBL2653229 | 0.81 | GCGR (0.47) | MEN1KMT2ASMN1; SMN2PPARAALDH1A1 | |
| SCHEMBL2654566 | 0.81 | KMT2A (0.54) | MEN1KMT2ASMN1; SMN2PPARAALDH1A1 | |
| SCHEMBL2655103 | 0.80 | GCGR (0.47) | MEN1KMT2ASMN1; SMN2PPARAPPARG | |
| SCHEMBL2653412 | 0.79 | PSEN1 (0.44) | SMN1; SMN2PPARAALDH1A1FABP2PPARG | |
| SCHEMBL2652666 | 0.78 | TRPV1 (0.46) | TRPV1 | |
| SCHEMBL1765815 | 0.76 | GCG (0.46) | — | |
| SCHEMBL2655085 | 0.76 | GCGR (0.46) | PPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |