Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRG | P62508 | 4/20 | 0.49 |
| ▸ | ESRRB | O95718 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | CTSG | P08311 | 1/20 | 0.42 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
| ▸ | FABP2 | P12104 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654794 | 0.83 | CYP4A11 (0.60) | ESRRGALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2655731 | 0.82 | CYP4A11 (0.58) | ESRRGALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2656528 | 0.82 | CYP4A11 (0.58) | ESRRGALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2656019 | 0.82 | CYP4A11 (0.58) | ESRRGALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL14551257 | 0.79 | PLK1 (0.57) | ESRRGESRRBALDH1A1RAB9ANPC1 | |
| SCHEMBL2653637 | 0.79 | CYP4A11 (0.67) | ALDH1A1MAPTPOLBCYP4A11CA1 | |
| SCHEMBL2654566 | 0.79 | KMT2A (0.54) | ESRRGALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2661394 | 0.79 | MEN1 (0.48) | ESRRGRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL13418128 | 0.78 | ESRRG (0.51) | ESRRGESRRBALDH1A1RAB9ANPC1 | |
| SCHEMBL15943202 | 0.76 | ESRRG (0.54) | ESRRGESRRBRAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |