SCHEMBL26545964

SCHEMBL26545964

O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)Nc1cccc(OF)c1OF

nearest known ligand 0.65

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KDR P35968 1/20 0.65
TRPV1 Q8NER1 18/20 0.65
CA1 P00915 1/20 0.58
CA2 P00918 1/20 0.58
CA7 P43166 1/20 0.58
CA9 Q16790 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19677976 0.81 KDR (0.88) KDRTRPV1CA1CA2CA7
SCHEMBL29364392 0.81 KDR (1.00) KDRTRPV1CA1CA2CA7
SCHEMBL118026 0.81 KDR (1.00) KDRTRPV1CA1CA2CA7
SCHEMBL6430968 0.80 KDR (0.70) KDRTRPV1
SCHEMBL8684088 0.79 KDR (0.74) KDRTRPV1
SCHEMBL14714426 0.79 TRPV1 (0.78) KDRTRPV1CA1CA2CA7
SCHEMBL9117619 0.78 TRPV1 (0.60) KDRTRPV1
SCHEMBL11187741 0.77 CA1 (0.71) KDRTRPV1CA1CA2CA7
SCHEMBL16884950 0.77 KDR (0.85) KDRTRPV1CA1CA2CA7
SCHEMBL18615348 0.77 KDR (0.85) KDRTRPV1CA1CA2CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230330061-A1 ANTIMICROBIAL COMPOSITIONS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF NATIONAL TAIWAN UNIVERSITY (TW) 2023-10-19 US disclosed
US-20230330061-A1 ANTIMICROBIAL COMPOSITIONS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF NATIONAL TAIWAN UNIVERSITY (TW) 2023-10-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230330061-A1 ANTIMICROBIAL COMPOSITIONS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF FASN, NAAA, FPR3 KDR 4172/4885TRPV1 199/4885CA1 4440/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.