Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 16/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30580742 | 0.82 | ALOX12 (1.00) | ALOX12ALOX15 | |
| SCHEMBL16646106 | 0.82 | ALOX12 (1.00) | ALOX12ALOX15 | |
| SCHEMBL26546263 | 0.82 | ALOX12 (0.70) | ALOX12MAPTGAAALOX15KDM4E | |
| SCHEMBL26546259 | 0.79 | ALOX12 (0.66) | ALOX12MAPTGAAALOX15KDM4E | |
| SCHEMBL26546267 | 0.79 | ALOX12 (0.68) | ALOX12MAPTGAAALOX15KDM4E | |
| SCHEMBL26546300 | 0.76 | ALOX12 (0.70) | ALOX12MAPTGAAALOX15KDM4E | |
| SCHEMBL16634464 | 0.75 | ALOX12 (1.00) | ALOX12ALOX15 | |
| SCHEMBL26546320 | 0.75 | ALOX12 (0.66) | ALOX12MAPTGAAALOX15KDM4E | |
| SCHEMBL26546203 | 0.72 | KDM4E (0.77) | ALOX12MAPTGAAALOX15KDM4E | |
| SCHEMBL26546120 | 0.72 | ALOX12 (0.65) | ALOX12MAPTGAAALOX15KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054936-B1 | 4-((2-HYDROXY-3-METHOXYBENZYL)AMINO) BENZENESULFONAMIDE DERIVATIVES AS 12-LIPOXYGENASE INHIBITORS | EASTERN VIRGINIA MEDICAL SCHOOL (US) | 2023-10-18 | — | — | EP | disclosed |