Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.64 |
| ▸ | GCGR | P47871 | 10/20 | 0.64 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2662944 | 0.76 | GCGR (0.60) | MAPK14GCGR | |
| SCHEMBL28912040 | 0.73 | GCGR (0.82) | MAPK14GCGR | |
| SCHEMBL7852542 | 0.71 | TGFBR1 (0.58) | MAPK14GCGRTGFBR1 | |
| SCHEMBL2662940 | 0.70 | GCGR (0.97) | MAPK14GCGR | |
| SCHEMBL2662559 | 0.70 | GCGR (1.00) | MAPK14GCGR | |
| SCHEMBL2646773 | 0.70 | GCGR (1.00) | MAPK14GCGR | |
| SCHEMBL31039970 | 0.69 | TGFBR1 (0.59) | MAPK14TGFBR1 | |
| SCHEMBL31039985 | 0.69 | L3MBTL1 (0.53) | TGFBR1 | |
| SCHEMBL1358217 | 0.68 | TGFBR1 (0.57) | MAPK14TGFBR1 | |
| SCHEMBL196552 | 0.68 | L3MBTL1 (0.64) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0859771-A4 | SUBSTITUTED PYRIDYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO INC (US) | 2000-03-15 | — | — | EP | claimed |
| EP-0859771-A1 | SUBSTITUTED PYRIDYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | Merck & Co., Inc. (US) | 1998-08-26 | — | — | EP | claimed |
| US-5776954-A | GLUCAGON ANTAGONISTS | MERCK & CO., INC. (US) | 1998-07-07 | — | — | US | claimed |
| WO-1997016442-A1 | SUBSTITUTED PYRIDYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 1997-05-09 | — | — | WO | claimed |
| US-5776954-A | GLUCAGON ANTAGONISTS | MERCK & CO., INC. (US) | 1998-07-07 | — | — | US | disclosed |
| WO-1997016442-A1 | SUBSTITUTED PYRIDYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 1997-05-09 | — | — | WO | disclosed |