Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7836036 | 0.85 | CYP4A11 (0.44) | DAOKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL2654739 | 0.79 | DAO (0.52) | DAOKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL7832722 | 0.78 | DAO (0.50) | DAOKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL6999104 | 0.78 | DAO (0.46) | DAOKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL2064505 | 0.75 | MAPT (0.50) | DAOKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL13269283 | 0.72 | KDM4E (0.44) | DAOKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL27760636 | 0.69 | GPR35 (0.51) | DAOKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL6999107 | 0.69 | KDM4E (0.54) | DAOKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL835069 | 0.69 | DAO (1.00) | DAOKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL2653080 | 0.68 | CYP4A11 (0.43) | DAOKDM4EALDH1A1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773943-A1 | COMPOUNDS USEFUL AS ANTIPROLIFERATIVE AGENTS AND GARFT INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996003406-A1 | COMPOUNDS USEFUL AS ANTIPROLIFERATIVE AGENTS AND GARFT INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 1996-02-08 | — | — | WO | disclosed |