Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MAOB | P27338 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2878771 | 1.00 | ALDH1A1 (0.48) | ALDH1A1KDM4EMAOBSMN1; SMN2MAOA | |
| SCHEMBL12366007 | 0.81 | KDM4E (0.44) | ALDH1A1KDM4EMAOBSMN1; SMN2MAOA | |
| SCHEMBL1279441 | 0.81 | KDM4E (0.66) | ALDH1A1KDM4ESMN1; SMN2HPGDL3MBTL4 | |
| SCHEMBL16333691 | 0.78 | MAOB (0.45) | ALDH1A1KDM4EMAOBSMN1; SMN2MAOA | |
| SCHEMBL23363326 | 0.75 | MAOB (0.45) | ALDH1A1KDM4EMAOBSMN1; SMN2MAOA | |
| SCHEMBL31457765 | 0.75 | MAOB (0.45) | ALDH1A1KDM4EMAOBSMN1; SMN2MAOA | |
| SCHEMBL552716 | 0.74 | GRM5 (0.56) | ALDH1A1KDM4EMAOBSMN1; SMN2MAOA | |
| SCHEMBL29446216 | 0.74 | GRM5 (0.47) | ALDH1A1KDM4EMAOBSMN1; SMN2MAOA | |
| SCHEMBL670311 | 0.74 | GRM5 (0.47) | ALDH1A1KDM4EMAOBSMN1; SMN2MAOA | |
| SCHEMBL17782662 | 0.74 | KDM4E (0.53) | ALDH1A1KDM4ESMN1; SMN2HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1868985-A2 | GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | Merck & Co., Inc. (US) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006104826-A2 | GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 2006-10-05 | — | — | WO | disclosed |