Sugi Predict

Sugi Predict / Compounds / SCHEMBL670311

SCHEMBL670311

SCHEMBL670311

COC(=O)c1ccc2c(c1)C(=O)CCO2

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GRM5 P41594 1/20 0.47
▸ MAOA P21397 1/20 0.45
▸ MAOB P27338 1/20 0.45
▸ SMN1; SMN2 Q16637 6/20 0.45
▸ ALDH1A1 P00352 4/20 0.45
▸ CA12 O43570 2/20 0.45
▸ CA9 Q16790 2/20 0.45
▸ ATM Q13315 1/20 0.45
▸ NPSR1 Q6W5P4 1/20 0.45
▸ TSHR P16473 2/20 0.44
▸ LMNA P02545 1/20 0.44
▸ MAPK1 P28482 1/20 0.44
▸ RAB9A P51151 5/20 0.44
▸ MEN1 O00255 4/20 0.44
▸ KMT2A Q03164 4/20 0.44
▸ NPC1 O15118 3/20 0.44
▸ MAPT P10636 3/20 0.44
▸ POLB P06746 2/20 0.44
▸ MCL1 Q07820 1/20 0.44
▸ KDM4E B2RXH2 3/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29446216 1.00 GRM5 (0.47) GRM5MAOAMAOBSMN1; SMN2ALDH1A1
SCHEMBL2260234 0.92 SMN1; SMN2 (0.46) SMN1; SMN2ALDH1A1CA12CA9ATM
SCHEMBL552716 0.88 GRM5 (0.56) GRM5MAOAMAOBSMN1; SMN2ALDH1A1
SCHEMBL22978668 0.85 GRM5 (0.43) GRM5MAOAMAOBSMN1; SMN2ALDH1A1
SCHEMBL9118239 0.85 CA12 (0.47) SMN1; SMN2ALDH1A1CA12CA9ATM
SCHEMBL6838633 0.85 GPR119 (0.48) GRM5MAOAMAOBSMN1; SMN2ALDH1A1
SCHEMBL6837071 0.83 KDM4E (0.55) GRM5MAOAMAOBATMNPSR1
SCHEMBL6293635 0.83 ALDH1A1 (0.51) GRM5MAOAMAOBALDH1A1TSHR
SCHEMBL803659 0.82 CYP2C9 (0.44) SMN1; SMN2ALDH1A1CA12CA9ATM
SCHEMBL3490016 0.80 PRKCI (0.57) SMN1; SMN2ALDH1A1CA12CA9TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12350270-B2 Antimalarial agents MSD R&D (CHINA) CO. LTD. (CN) 2025-07-08 — — US disclosed
US-20230355622-A1 METHODS OF CHEMOVACCINATION AGAINST PLASMODIUM INFECTIONS MERCK SHARP & DOHME LLC (US) 2023-11-09 — — US disclosed
US-20230355622-A1 METHODS OF CHEMOVACCINATION AGAINST PLASMODIUM INFECTIONS MERCK SHARP & DOHME LLC (US) 2023-11-09 — — US disclosed
US-20230355622-A1 METHODS OF CHEMOVACCINATION AGAINST PLASMODIUM INFECTIONS MERCK SHARP & DOHME LLC (US) 2023-11-09 — — US disclosed
EP-4216957-A1 METHODS OF CHEMOVACCINATION AGAINST PLASMODIUM INFECTIONS Merck Sharp & Dohme LLC (US) 2023-08-02 — — EP disclosed
US-20220331321-A1 ANTIMALARIAL AGENTS MERCK SHARP & DOHME CORP. (US) 2022-10-20 — — US disclosed
US-20220331321-A1 ANTIMALARIAL AGENTS MERCK SHARP & DOHME CORP. (US) 2022-10-20 — — US disclosed
EP-4013742-A1 ANTIMALARIAL AGENTS Merck Sharp & Dohme Corp. (US) 2022-06-22 — — EP disclosed
CN-114555564-A Antimalarial drugs 默沙东公司 2022-05-27 — — CN disclosed
WO-2022066545-A1 METHODS OF CHEMOVACCINATION AGAINST PLASMODIUM INFECTIONS MERCK SHARP & DOHME CORP. (US) 2022-03-31 — — WO disclosed
US-20130131042-A1 SPIROXAZOLIDINONE COMPOUNDS MERCK SHARP & DOHME CORP. (US) 2013-05-23 — — US disclosed
US-20130131042-A1 SPIROXAZOLIDINONE COMPOUNDS MERCK SHARP & DOHME CORP. (US) 2013-05-23 — — US disclosed
WO-2012038081-A1 SUBSTITUTED BENZAMIDE COMPOUNDS Grünenthal GmbH (DE) 2012-03-29 — — WO disclosed
US-20120071461-A1 Substituted Benzamide Compounds GRUENENTHAL GMBH (DE) 2012-03-22 — — US disclosed
US-20120071461-A1 Substituted Benzamide Compounds GRUENENTHAL GMBH (DE) 2012-03-22 — — US disclosed
WO-2012024183-A1 SPIROXAZOLIDINONE COMPOUNDS MERCK SHARP & DOHME CORP. (US) 2012-02-23 — — WO disclosed
WO-2012024183-A1 SPIROXAZOLIDINONE COMPOUNDS MERCK SHARP & DOHME CORP. (US) 2012-02-23 — — WO disclosed
US-6756432-B2 POLYBUTADIENE TYPE POLYMER WITH A 1-BENZOPYRAN, A 1-BENZO PYRAN-2-ONE OR A BENZOIN DERIVATIVE; MOLDS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2004-06-29 — — US disclosed
US-20030153655-A1 Polybutadiene composition SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-08-14 — — US disclosed
US-5405844-A Tetracyclic antibiotics and processes for their preparation HOECHST AKTIENGESELLSCHAFT (DE) 1995-04-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12350270-B2 Antimalarial agents CTSL, SERPINA3, SERPINB1 GRM5 4079/4885MAOA 2693/4885MAOB 2711/4885
US-20230355622-A1 METHODS OF CHEMOVACCINATION AGAINST PLASMODIUM INFECTIONS CTSL, PRCP, CPB1 GRM5 3487/4885MAOA 4099/4885MAOB 4140/4885
US-20220331321-A1 ANTIMALARIAL AGENTS CTSL, SERPINA3, SERPINB1 GRM5 4079/4885MAOA 2693/4885MAOB 2711/4885
US-20130131042-A1 SPIROXAZOLIDINONE COMPOUNDS SSTR5, SSTR2, SSTR4 GRM5 94/4885MAOA 968/4885MAOB 1038/4885
US-20120071461-A1 Substituted Benzamide Compounds BDKRB1, BDKRB2, HRH2 GRM5 1742/4885MAOA 726/4885MAOB 261/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.