Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4A11 | Q02928 | 4/20 | 0.60 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ESRRG | P62508 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | CTSG | P08311 | 1/20 | 0.47 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.47 |
| ▸ | CMA1 | P23946 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656019 | 0.99 | CYP4A11 (0.58) | CYP4A11CYP4F2POLBALDH1A1ESRRG | |
| SCHEMBL2655731 | 0.99 | CYP4A11 (0.58) | CYP4A11CYP4F2POLBALDH1A1ESRRG | |
| SCHEMBL2656528 | 0.99 | CYP4A11 (0.58) | CYP4A11CYP4F2POLBALDH1A1ESRRG | |
| SCHEMBL14551257 | 0.84 | PLK1 (0.57) | POLBALDH1A1ESRRGNPC1RAB9A | |
| SCHEMBL2653473 | 0.83 | ESRRG (0.49) | CYP4A11CYP4F2POLBALDH1A1ESRRG | |
| SCHEMBL13418128 | 0.83 | ESRRG (0.51) | ALDH1A1ESRRGNPC1RAB9APRSS1 | |
| SCHEMBL2655863 | 0.82 | MAPT (0.43) | CYP4A11CYP4F2POLBALDH1A1ESRRG | |
| SCHEMBL2402293 | 0.81 | PLK1 (0.53) | POLBALDH1A1ESRRGNPC1RAB9A | |
| SCHEMBL9673644 | 0.81 | CYP4A11 (0.63) | CYP4A11CYP4F2 | |
| SCHEMBL2653059 | 0.80 | NPC1 (0.53) | ALDH1A1ESRRGNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |