Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.58 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | ESRRG | P62508 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | CTSG | P08311 | 1/20 | 0.46 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656019 | 1.00 | CYP4A11 (0.58) | CYP4A11CYP4F2POLBNPC1RAB9A | |
| SCHEMBL2655731 | 1.00 | CYP4A11 (0.58) | CYP4A11CYP4F2POLBNPC1RAB9A | |
| SCHEMBL2654794 | 0.99 | CYP4A11 (0.60) | CYP4A11CYP4F2POLBNPC1RAB9A | |
| SCHEMBL14551257 | 0.83 | PLK1 (0.57) | POLBNPC1RAB9AALDH1A1ESRRG | |
| SCHEMBL9673644 | 0.82 | CYP4A11 (0.63) | CYP4A11CYP4F2HDAC1 | |
| SCHEMBL2653473 | 0.82 | ESRRG (0.49) | CYP4A11CYP4F2POLBNPC1RAB9A | |
| SCHEMBL2653059 | 0.82 | NPC1 (0.53) | NPC1RAB9AALDH1A1ESRRGSMN1; SMN2 | |
| SCHEMBL2661669 | 0.82 | NPC1 (0.62) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL13418128 | 0.82 | ESRRG (0.51) | NPC1RAB9AALDH1A1ESRRGPRSS1 | |
| SCHEMBL2654532 | 0.81 | HSP90AA1 (0.53) | NPC1RAB9AALDH1A1HSP90AA1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951659-A2 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | Eli Lilly & Company (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007114855-A2 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-10-11 | — | — | WO | disclosed |