Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR6 | P51684 | 1/20 | 0.45 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655148 | 0.86 | HSP90AA1 (0.46) | KMT2AHSP90AA1ALDH1A1MAOANPC1 | |
| SCHEMBL2653361 | 0.82 | NPC1 (0.49) | KMT2AHSP90AA1ALDH1A1CYP1A2HPGD | |
| SCHEMBL2653558 | 0.78 | CYP4A11 (0.56) | CCR6HKDC1CYP4A11CYP4F2KMT2A | |
| SCHEMBL2653681 | 0.76 | CYP4A11 (0.61) | CCR6HKDC1CYP4A11CYP4F2KMT2A | |
| SCHEMBL2585292 | 0.75 | KMT2A (0.49) | CYP4A11KMT2AALDH1A1HPGDLOXL2 | |
| SCHEMBL1018394 | 0.74 | KMT2A (0.48) | CYP4A11KMT2AALDH1A1HPGDLOXL2 | |
| SCHEMBL1253696 | 0.74 | KMT2A (0.48) | CYP4A11KMT2AALDH1A1HPGDLOXL2 | |
| SCHEMBL1018393 | 0.74 | KMT2A (0.48) | CYP4A11KMT2AALDH1A1HPGDLOXL2 | |
| SCHEMBL8293519 | 0.74 | CYP4A11 (0.62) | CCR6HKDC1CYP4A11CYP4F2KMT2A | |
| SCHEMBL29055656 | 0.72 | CYP4A11 (0.60) | CCR6HKDC1CYP4A11CYP4F2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |