Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | SDCBP | O00560 | 1/20 | 0.39 |
| ▸ | SDC2 | P34741 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654795 | 0.86 | CCR6 (0.45) | HSP90AA1KMT2AMAOANPC1RAB9A | |
| SCHEMBL2653361 | 0.79 | NPC1 (0.49) | HSP90AA1KMT2ANPC1RAB9APOLB | |
| SCHEMBL3889931 | 0.75 | MAOB (0.54) | HSP90AA1KMT2AMAOARXRARXRB | |
| SCHEMBL2655029 | 0.74 | ALDH1A1 (0.50) | KMT2ARXRARXRBRARBALDH1A1 | |
| SCHEMBL11527703 | 0.74 | ALDH1A1 (0.55) | KMT2ARXRARXRBRARBALDH1A1 | |
| SCHEMBL9144768 | 0.74 | ALDH1A1 (0.55) | KMT2ARXRARXRBRARBALDH1A1 | |
| SCHEMBL6487970 | 0.73 | HTT (0.50) | KMT2AMAOARARBALDH1A1SMN1; SMN2 | |
| SCHEMBL31632675 | 0.72 | HTT (0.49) | KMT2AMAOAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL104594 | 0.71 | GRIN2D (0.57) | KMT2ARXRARXRBPOLBRARB | |
| SCHEMBL11358358 | 0.70 | RARB (0.61) | KMT2ARXRARXRBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |