Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 12/20 | 0.64 |
| ▸ | RXRB | P28702 | 9/20 | 0.64 |
| ▸ | RARB | P10826 | 8/20 | 0.36 |
| ▸ | RARG | P13631 | 8/20 | 0.36 |
| ▸ | RXRG | P48443 | 6/20 | 0.36 |
| ▸ | RARA | P10276 | 6/20 | 0.35 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | BLVRB | P30043 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP26B1 | Q9NR63 | 3/20 | 0.34 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6570592 | 0.83 | RXRA (0.64) | RXRARXRBRARBRARGRXRG | |
| SCHEMBL6147714 | 0.72 | RXRA (0.55) | RXRARXRBRARBRARGRXRG | |
| SCHEMBL7714822 | 0.72 | RXRA (0.51) | RXRARXRBRARBRARGRXRG | |
| SCHEMBL1619225 | 0.71 | RXRA (0.53) | RXRARXRB | |
| SCHEMBL14492781 | 0.71 | RXRA (0.53) | RXRARXRB | |
| SCHEMBL6146095 | 0.71 | RXRA (0.54) | RXRARXRBRARBRARGRXRG | |
| SCHEMBL6147245 | 0.71 | RXRA (0.50) | RXRARXRBRARBRARGRXRG | |
| SCHEMBL14492793 | 0.70 | RXRA (0.52) | RXRARXRBMEN1KMT2A | |
| SCHEMBL1619281 | 0.70 | RXRA (0.52) | RXRARXRBMEN1KMT2A | |
| SCHEMBL6147894 | 0.70 | RXRA (0.64) | RXRARXRBRARBRARGRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951707-A1 | SUBSTITUTED PYRROLONES AS ALLOSTERIC MODULATORS OF GLUCOKINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007053657-A1 | SUBSTITUTED PYRROLONES AS ALLOSTERIC MODULATORS OF GLUCOKINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-10 | — | — | WO | disclosed |