Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 14/20 | 0.51 |
| ▸ | RXRB | P28702 | 10/20 | 0.51 |
| ▸ | RARB | P10826 | 10/20 | 0.39 |
| ▸ | RARG | P13631 | 9/20 | 0.39 |
| ▸ | RARA | P10276 | 7/20 | 0.39 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | BLVRB | P30043 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7714855 | 0.79 | RXRA (0.47) | RXRARXRBRARBRARGRARA | |
| SCHEMBL8441961 | 0.75 | RXRA (0.66) | RXRARXRBRARBRARGRARA | |
| SCHEMBL8839185 | 0.74 | RXRA (0.62) | RXRARXRBRARBRARGRARA | |
| SCHEMBL8730978 | 0.74 | RXRA (0.51) | RXRARXRBRARBRARGRARA | |
| SCHEMBL6146095 | 0.73 | RXRA (0.54) | RXRARXRBRARBRARGRARA | |
| SCHEMBL6147245 | 0.73 | RXRA (0.50) | RXRARXRBRARBRARGRARA | |
| SCHEMBL6147894 | 0.72 | RXRA (0.64) | RXRARXRBRARBRARGRARA | |
| SCHEMBL2654848 | 0.72 | RXRA (0.64) | RXRARXRBRARBRARGRARA | |
| SCHEMBL8681677 | 0.72 | RARB (0.67) | RXRARXRBRARBRARGRARA | |
| SCHEMBL17210661 | 0.72 | MEN1 (0.39) | CYP3A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6368608-B1 | SKIN DISORDERS | CENTRE INTERNATIONAL DE RECHERCHE DERMATOLOGIQUES GALDERMA (C.I.R.D.) (FR) | 2002-04-09 | — | — | US | disclosed |
| US-6162445-A | Polyaromatic propynyl compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-12-19 | — | — | US | disclosed |
| EP-0661258-B1 | Biaromatic propynyl compounds, pharmaceutical compositions and cosmetics containing them and their uses | CIRD GALDERMA (FR) | 1998-04-08 | — | — | EP | disclosed |
| US-5716624-A | USEFUL FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, OPTHALMOLOGICAL DISORDERS, AS WELL AS MAMMALIAN SKIN AND HAIR CONDITIONS/DISORDERS | C.I.R.D. GALDERMA (FR) | 1998-02-10 | — | — | US | disclosed |
| EP-0661258-A1 | Biaromatic propynyl compounds, pharmaceutical compositions and cosmetics containing them and their uses | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA) (FR) | 1995-07-05 | — | — | EP | disclosed |