Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 3/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652866 | 0.92 | GCGR (0.43) | GCGRPPARAPPARDPPARGKMT2A | |
| SCHEMBL2653251 | 0.91 | GCGR (0.37) | GCGRMAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL2654086 | 0.90 | GCGR (0.40) | HPGDGCGRMAPTKDM4ELMNA | |
| SCHEMBL2654294 | 0.87 | MEN1 (0.41) | HPGDMAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL2653339 | 0.87 | GCGR (0.42) | GCGRPPARAPPARDPPARG | |
| SCHEMBL2653034 | 0.86 | HPGD (0.43) | HPGDMAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL2653431 | 0.85 | HPGD (0.47) | HPGDMAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL2662283 | 0.84 | MEN1 (0.46) | GCGRSPHK2ADRB2ADRB1TP53 | |
| SCHEMBL2655151 | 0.83 | PPARA (0.39) | HPGDMAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL2655260 | 0.83 | GCGR (0.45) | GCGRPPARAPPARDPPARGKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |