Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC10A2 | Q12908 | 6/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654017 | 0.73 | OPRM1 (0.32) | SLC10A2KDM1AMAOAMAOBKDM4E | |
| SCHEMBL2653461 | 0.73 | CHRNA7 (0.30) | KDM1AMAOAMAOB | |
| SCHEMBL30939676 | 0.69 | SLC10A2 (0.33) | SLC10A2KDM4EPKM | |
| SCHEMBL23396586 | 0.59 | KDM1A (0.37) | KDM1AMAOAMAOB | |
| SCHEMBL11833585 | 0.59 | KDM1A (0.39) | SLC10A2KDM1AMAOAMAOBKDM4E | |
| SCHEMBL10674140 | 0.58 | KDM1A (0.38) | KDM1AMAOAMAOB | |
| SCHEMBL9852458 | 0.57 | OPRM1 (0.39) | KDM1AMAOAMAOBOPRM1OPRD1 | |
| Phenol SCHEMBL27513359 | 0.56 | CA12 (0.61) | KDM4EOPRM1OPRD1OPRK1 | |
| Phenol SCHEMBL27577782 | 0.56 | CA12 (0.61) | KDM4EOPRM1OPRD1OPRK1 | |
| Phenol SCHEMBL28185432 | 0.56 | CA12 (0.61) | KDM4EOPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |