SCHEMBL26549082

SCHEMBL26549082

C[Si](C)(C)c1ccc(-c2ccc3cc(-c4ccc(-c5cccc6cccnc56)cc4)cnc3c2)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAK O14976 1/20 0.40
NPC1 O15118 1/20 0.40
POLB P06746 1/20 0.40
RAB9A P51151 1/20 0.40
PDGFRB P09619 4/20 0.39
PDGFRA P16234 4/20 0.39
CCR1 P32246 2/20 0.39
CCR5 P51681 2/20 0.39
CCR8 P51685 2/20 0.39
ACVRL1 P37023 1/20 0.39
ACVR1 Q04771 1/20 0.39
ESR2 Q92731 1/20 0.39
KDM4E B2RXH2 2/20 0.38
MMP9 P14780 2/20 0.38
GMNN O75496 1/20 0.38
LMNA P02545 1/20 0.38
TP53 P04637 1/20 0.38
HSP90AA1 P07900 1/20 0.38
MMP2 P08253 1/20 0.38
CYP3A4 P08684 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26549377 1.00 GAK (0.40) GAKNPC1POLBRAB9APDGFRB
SCHEMBL26549245 0.91 GAK (0.38) GAKNPC1POLBRAB9APDGFRB
SCHEMBL26548420 0.89 CCR1 (0.46) NPC1POLBRAB9ACCR1CCR5
SCHEMBL26548009 0.89 CCR1 (0.46) NPC1POLBRAB9ACCR1CCR5
SCHEMBL26548925 0.87 CCR1 (0.44) NPC1POLBRAB9ACCR1CCR5
SCHEMBL26548603 0.87 CCR1 (0.44) NPC1POLBRAB9ACCR1CCR5
SCHEMBL26570272 0.85 NPC1 (0.42) GAKNPC1POLBRAB9APDGFRB
SCHEMBL26549372 0.85 TOP1 (0.47) GAKNPC1POLBRAB9APDGFRB
SCHEMBL26549078 0.85 TOP1 (0.47) GAKNPC1POLBRAB9APDGFRB
SCHEMBL26558290 0.85 NPC1 (0.42) GAKNPC1POLBRAB9APDGFRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230337527-A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME LAPTO CO., LTD. (KR) 2023-10-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230337527-A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME AOC1, ODC1, PIEZO1 GAK 3896/4885NPC1 1199/4885POLB 1720/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.