PIEZO1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL10563043	0.51	13/20
SCHEMBL17695699	0.56	12/20
SCHEMBL17695671	0.51	12/20
SCHEMBL17695693	0.54	11/20
SCHEMBL17695691	0.57	10/20
SCHEMBL15599488	0.43	10/20
SCHEMBL23195352	0.69	9/20
SCHEMBL17695696	0.57	9/20
SCHEMBL23195769	0.73	6/20
SCHEMBL6490578	1.00	5/20
SCHEMBL23195361	0.83	5/20
SCHEMBL23195706	0.81	5/20
SCHEMBL23195699	0.78	5/20
SCHEMBL23195760	0.74	5/20
SCHEMBL31520557	0.73	5/20
SCHEMBL31520562	0.73	5/20
SCHEMBL23195828	0.65	5/20
SCHEMBL23195365	0.62	5/20
SCHEMBL6489553	0.53	5/20
SCHEMBL17695687	0.48	5/20

Clinical trials — most relevant to PIEZO1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Low-Intensity Extracorporeal Shockwave Therapy on Penile Rehabilitation After Robot-assisted Surgical Treatment of Genitourinary Cancers	PHASE3	RECRUITING
Benefits of a Cannabidiolic Acid Topical Cream for the Treatment of Restless Leg Syndrome	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
Biomechanical Analysis of Distal Radius (Greenstick) Fracture Healing	PHASE1/PHASE2	NOT_YET_RECRUITING
Vibration Therapy Effects on Muscle Firing Patterns	PHASE1/PHASE2	COMPLETED
Modulation of Central Hypersensitivity in Chronic Musculoskeletal Pain by Intravenous Tropisetron	PHASE2	COMPLETED
Microneurographic Assessment of Peripheral Nerves in Healthy Volunteers and Individuals With Sensory Dysfunction Caused by Inherited Mutations in the PIEZO2 Gene	nan	RECRUITING
Cell Membrane Potential Regulates Spatial-Specific Mechanoptosis Resistance and Metastasis in Colorectal Cancer Via Mechanotransduction and the PVR/CD96 Axis	nan	COMPLETED
Piezo2-related Arthrogryposis & physiopathOLOgy 3	nan	NOT_YET_RECRUITING
Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain	nan	RECRUITING
Ultrasonic Surgical Aspirator to Treat Deep Infrabony Defects	nan	COMPLETED
Micromechanical Modeling Using Low Magnitude Mechanical Stimulation	nan	COMPLETED
The Role of the Rate of Force Application in Responses to Spinal Manipulation Therapy	nan	COMPLETED
Bone Microarchitecture at the Radius: a Pilot Comparison Between Children With Cystic Fibrosis and Healthy Controls	nan	COMPLETED
Effect of Radius on Alpha Motor Neuron Excitability	nan	COMPLETED
Effect of Bone on Vibration-Induced Muscle Strength Gain	nan	COMPLETED
Vibration as a Method of Fracture Screening in Children	nan	COMPLETED
Metabolic Profile of Bone in Professional Athletes	nan	RECRUITING
Evaluation of Marginal Bone Loss Using Computer Guided Ridge Splitting Technique With Simultaneous Implant Placement.	nan	UNKNOWN
Effect of Bone on Vibration-Induced Muscle Electrical Activity	nan	COMPLETED
Efficacy and Safety Trial of Using Ultra-Pulsed Shockwaves to Deliver Tranexamic Acid for the Treatment of Melasma	nan	UNKNOWN
The Effect of Taping in Reducing the Intensity of Pain in Primary Dysmenorrhea	nan	COMPLETED
Bone Myoregulation Reflex in Senile Osteoporosis	nan	COMPLETED
Oral Ketamine as an Adjuvant to Opioids for Pain Treatment in Cancer Patients	nan	UNKNOWN
Physical Activity and Sarcoma, Role and Impact on Outcome	nan	NOT_YET_RECRUITING
Labor Education to Reduce Postpartum Traumatic Stress	nan	ACTIVE_NOT_RECRUITING
Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin	nan	ENROLLING_BY_INVITATION
Biometric and Biological Data for Diagnosis and Therapy of Pain Patients	nan	UNKNOWN
Reflex Activity During Bone-Loading Exercises	nan	COMPLETED
Effectiveness of Kinesiotaping in Primary Dysmenorrhea	nan	COMPLETED
Impact of Peripheral Afferent Input on Central Neuropathic Pain	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a PIEZO1 binder may also engage these)

Protein	Name	Similarity
E2JF22	—	1.000	E2JF22 →
Q0KL00	—	1.000	Q0KL00 →
Q8CD54	—	0.989	Q8CD54 →
Q6PH58	—	0.988	Q6PH58 →
STRA6	Receptor for retinol uptake STRA6	0.986	landscape →
Q9H5I5	—	0.986	Q9H5I5 →
Q8R115	—	0.985	Q8R115 →
A0PJX8	—	0.984	A0PJX8 →
PIGO	GPI ethanolamine phosphate transferase 3, catalytic subunit	0.984	landscape →
Q5R7B4	—	0.984	Q5R7B4 →
P28230	—	0.983	P28230 →
Q4QR83	—	0.982	Q4QR83 →
Q8N3F9	—	0.981	Q8N3F9 →
Q49LS7	—	0.981	Q49LS7 →
Q7M734	—	0.981	Q7M734 →
Q6GMB1	—	0.981	Q6GMB1 →
Q8NFK1	—	0.981	Q8NFK1 →
Q6DF19	—	0.981	Q6DF19 →
Q0V8E7	—	0.981	Q0V8E7 →
O95377	—	0.981	O95377 →
Q28FG4	—	0.981	Q28FG4 →
P08033	—	0.981	P08033 →
P35212	—	0.981	P35212 →
P08034	—	0.981	P08034 →
Q4VV71	—	0.980	Q4VV71 →
Q9CRG1	—	0.980	Q9CRG1 →
Q6WGK6	—	0.980	Q6WGK6 →
O70491	—	0.980	O70491 →
Q0IHF1	—	0.980	Q0IHF1 →
A4IFL1	—	0.980	A4IFL1 →