Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 10/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | GIPR | P48546 | 2/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | GCG | P01275 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | GLP1R | P43220 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656116 | 0.92 | GCGR (0.55) | GCGRMEN1KMT2AGIPRPPARD | |
| SCHEMBL2656001 | 0.92 | GCGR (0.51) | GCGRMEN1KMT2AMAPT | |
| SCHEMBL2655056 | 0.92 | GCGR (0.47) | GCGRMEN1KMT2AMAPTROCK2 | |
| SCHEMBL2657426 | 0.91 | GCGR (0.46) | GCGRMAPTROCK2ROCK1GIPR | |
| SCHEMBL2653285 | 0.87 | GCGR (0.45) | GCGRMEN1KMT2AMAPTGIPR | |
| SCHEMBL2655857 | 0.86 | GCGR (0.46) | GCGRMAPTPPARDPPARAGCG | |
| SCHEMBL2655157 | 0.85 | GCGR (0.60) | GCGR | |
| SCHEMBL2653577 | 0.85 | GCGR (0.51) | GCGRMEN1KMT2AMAPT | |
| SCHEMBL2654697 | 0.85 | GCGR (0.55) | GCGRGIPRPPARDPPARAGCG | |
| SCHEMBL2655051 | 0.85 | GCGR (0.55) | GCGRGIPRPPARDPPARAGCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951659-A2 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | Eli Lilly & Company (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007114855-A2 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-10-11 | — | — | WO | disclosed |