Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4A11 | Q02928 | 4/20 | 0.57 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31753749 | 0.99 | CYP4A11 (0.59) | CYP4A11CYP4F2POLBNPC1DPP4 | |
| SCHEMBL27359234 | 0.88 | NPC1 (0.56) | CYP4A11CYP4F2POLBNPC1DPP4 | |
| SCHEMBL20178618 | 0.87 | ALDH1A1 (0.47) | CYP4A11CYP4F2NPC1DPP4ALDH1A1 | |
| SCHEMBL19304427 | 0.85 | L3MBTL1 (0.48) | CYP4A11NPC1DPP4CA2ALDH1A1 | |
| SCHEMBL23309281 | 0.82 | CYP4A11 (0.58) | CYP4A11CYP4F2POLBNPC1DPP4 | |
| SCHEMBL3653076 | 0.82 | DPP4 (0.51) | CYP4A11CYP4F2NPC1DPP4CA2 | |
| SCHEMBL25933615 | 0.82 | DPP4 (0.48) | CYP4A11CYP4F2NPC1DPP4CA2 | |
| SCHEMBL31752834 | 0.82 | DPP4 (0.43) | CYP4A11CYP4F2NPC1DPP4CA2 | |
| SCHEMBL27150109 | 0.82 | DPP4 (0.50) | CYP4A11CYP4F2NPC1DPP4CA2 | |
| Hydrochloric Acid SCHEMBL12499484 | 0.81 | DPP4 (0.50) | CYP4A11CYP4F2NPC1DPP4CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |