Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 2/20 | 0.34 |
| ▸ | PPARA | Q07869 | 2/20 | 0.34 |
| ▸ | GCGR | P47871 | 7/20 | 0.34 |
| ▸ | GIPR | P48546 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655009 | 0.94 | GCGR (0.40) | PPARDPPARAGCGRGIPRFFAR1 | |
| SCHEMBL2654060 | 0.86 | GCGR (0.40) | GCGRGIPR | |
| SCHEMBL2656241 | 0.84 | PPARD (0.42) | ROCK2ROCK1MEN1KMT2APPARD | |
| SCHEMBL2662283 | 0.83 | MEN1 (0.46) | ROCK2ROCK1MEN1KMT2AGCGR | |
| SCHEMBL1765320 | 0.83 | GCGR (0.48) | GCGRGIPR | |
| SCHEMBL1765317 | 0.83 | GCGR (0.48) | GCGRGIPR | |
| SCHEMBL2654250 | 0.80 | NPC1 (0.41) | GCGRGIPRCA12CA1CA2 | |
| SCHEMBL2655056 | 0.79 | GCGR (0.47) | ROCK2ROCK1MEN1KMT2APPARD | |
| SCHEMBL2654589 | 0.78 | GCGR (0.48) | PPARDGCGRGIPRFFAR1FFAR4 | |
| SCHEMBL2657119 | 0.77 | NR1H4 (0.47) | MEN1KMT2AGCGRCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |