Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 13/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 13/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 13/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 12/20 | 0.51 |
| ▸ | GABRA2 | P47869 | 11/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2657599 | 0.89 | GABRG2 (0.48) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL341244 | 0.86 | GABRA1 (0.67) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL341530 | 0.84 | GABRG2 (0.55) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7002125 | 0.83 | GABRA1 (0.47) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2657562 | 0.83 | GABRG2 (0.51) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL341569 | 0.82 | GABRG2 (0.55) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2659313 | 0.82 | GABRG2 (0.76) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2653685 | 0.81 | GABRG2 (0.51) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2658448 | 0.80 | GABRG2 (0.50) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2659091 | 0.80 | GABRA1 (0.45) | GABRG2GABRB3GABRA3GABRA1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107967-A2 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR TREATING ANXIETY AND ENHANCING COGNITION | MERCK SHARP & DOHME LTD. (GB) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012505-A2 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR TREATING ANXIETY AND ENHANCING COGNITION | MERCK SHARP & DOHME LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |