Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.56 |
| ▸ | NPC1 | O15118 | 8/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | CASP2 | P42575 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4915134 | 0.79 | SCD (0.61) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL24847460 | 0.78 | KDM4E (0.52) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL24847397 | 0.78 | CCNE1 (0.52) | SMN1; SMN2KMT2AMEN1TSHRLMNA | |
| SCHEMBL4914811 | 0.78 | SCD (0.66) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4921043 | 0.78 | ALDH1A1 (0.55) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4918031 | 0.77 | NPC1 (0.63) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4917530 | 0.77 | KMT2A (0.57) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL14243031 | 0.76 | LCK (0.41) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4917961 | 0.76 | ALDH1A1 (0.54) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4923647 | 0.76 | RAB9A (0.64) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735322-A1 | SULFONAMIDE-THIAZOLPYRIDINE DERIVATIVES AS GLUCOKINASE ACTIVATORS USEFUL THE TREATMENT OF TYPE 2 DIABETES | Novartis AG (CH) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005095418-A1 | SULFONAMIDE-THIAZOLPYRIDINE DERIVATIVES AS GLUCOKINASE ACTIVATORS USEFUL THE TREATMENT OF TYPE 2 DIABETES | NOVARTIS AG (CH) | 2005-10-13 | — | — | WO | disclosed |