Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 16/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.43 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2658141 | 0.84 | GCK (0.43) | GCKKCNH2 | |
| SCHEMBL1427361 | 0.83 | GCK (0.51) | GCKKCNH2 | |
| SCHEMBL2654780 | 0.82 | CHRNB2 (0.48) | GCKKCNH2 | |
| SCHEMBL1427229 | 0.79 | GCK (0.64) | GCKKCNH2 | |
| SCHEMBL4783311 | 0.79 | GCK (0.64) | GCKKCNH2 | |
| SCHEMBL2660380 | 0.78 | GCK (0.65) | GCKKCNH2 | |
| SCHEMBL1427033 | 0.78 | GRM5 (0.53) | GCK | |
| SCHEMBL1427153 | 0.78 | GCK (0.65) | GCKKCNH2 | |
| SCHEMBL1776589 | 0.76 | GRM5 (0.55) | — | |
| SCHEMBL1653673 | 0.76 | GCK (0.51) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756076-A1 | HETROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005121110-A1 | HETROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES | ASTRAZENECA AB (SE) | 2005-12-22 | — | — | WO | disclosed |