Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 9/20 | 0.51 |
| ▸ | GIPR | P48546 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | PPARD | Q03181 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
| ▸ | GLP1R | P43220 | 2/20 | 0.41 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2651132 | 0.96 | GCGR (0.52) | GCGRGIPRMEN1KMT2AMAPK14 | |
| SCHEMBL2652916 | 0.96 | GCGR (0.52) | GCGRGIPRMEN1KMT2AMAPK14 | |
| SCHEMBL2653634 | 0.90 | MEN1 (0.49) | GCGRGIPRMEN1KMT2AMAPK14 | |
| SCHEMBL2653662 | 0.84 | MEN1 (0.55) | GCGRGIPRMEN1KMT2AMAPK14 | |
| SCHEMBL2653574 | 0.84 | MEN1 (0.55) | GCGRGIPRMEN1KMT2AMAPK14 | |
| SCHEMBL2654122 | 0.84 | MEN1 (0.55) | GCGRGIPRMEN1KMT2AMAPK14 | |
| SCHEMBL2654985 | 0.84 | MEN1 (0.55) | GCGRGIPRMEN1KMT2AMAPK14 | |
| SCHEMBL2652886 | 0.84 | MEN1 (0.55) | GCGRGIPRMEN1KMT2AMAPK14 | |
| SCHEMBL2661613 | 0.84 | MEN1 (0.55) | GCGRGIPRMEN1KMT2AMAPK14 | |
| SCHEMBL2652235 | 0.84 | MEN1 (0.55) | GCGRGIPRMEN1KMT2AMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | claimed |
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |