SCHEMBL26553722

SCHEMBL26553722

COC(=O)[C@H]1O[C@@H](n2cnc3c(NC(=O)c4ccccc4)ncnc32)[C@@H](OC)C1C

nearest known ligand 0.60

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ PRMT6 Q96LA8 1/20 0.48
▸ AHCY P23526 1/20 0.47
▸ ADORA3 P0DMS8 3/20 0.46
▸ ADORA2A P29274 4/20 0.46
▸ ADORA2B P29275 4/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26553730 0.94 ADORA2A (0.51) PRMT6ADORA3ADORA2AADORA2B
SCHEMBL18464846 0.87 PRMT6 (0.53) PRMT6ADORA3ADORA2AADORA2B
SCHEMBL26553789 0.87 PRMT6 (0.53) PRMT6ADORA3ADORA2AADORA2B
SCHEMBL25765149 0.87 PRMT6 (0.53) PRMT6ADORA3
SCHEMBL26554294 0.87 PRMT6 (0.48) PRMT6ADORA3ADORA2AADORA2B
SCHEMBL26553794 0.87 PRMT6 (0.53) PRMT6ADORA3
SCHEMBL10889457 0.84 ADORA3 (0.58) AHCYADORA3ADORA2AADORA2B
SCHEMBL12700006 0.83 PRMT6 (0.54) PRMT6ADORA3ADORA2AADORA2B
SCHEMBL1582757 0.81 MEN1 (0.63) ADORA3ADORA2AADORA2B
SCHEMBL20454454 0.81 MEN1 (0.63) ADORA3ADORA2AADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230365970-A1 Modified Short Interfering Nucleic Acid (siNA) Molecules and Uses Thereof ALIGOS THERAPEUTICS, INC. (US) 2023-11-16 — — US disclosed
US-20230332153-A1 Modified Short Interfering Nucleic Acid (siNA) Molecules and Uses Thereof ALIGOS THERAPEUTICS, INC. (US) 2023-10-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230365970-A1 Modified Short Interfering Nucleic Acid (siNA) Molecules and Uses Thereof NSUN2, SNRPA, SNRPF PRMT6 1699/4885AHCY 3101/4885ADORA3 1358/4885
US-20230332153-A1 Modified Short Interfering Nucleic Acid (siNA) Molecules and Uses Thereof NSUN2, SNRPA, SNRPF PRMT6 1699/4885AHCY 3101/4885ADORA3 1358/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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