Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | APP | P05067 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.69 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.69 |
| ▸ | F7 | P08709 | 1/20 | 0.61 |
| ▸ | F3 | P13726 | 1/20 | 0.61 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.61 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.61 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.61 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.61 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.61 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.61 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.61 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27972556 | 0.98 | ALDH1A1 (0.67) | ALDH1A1APPGAAHCAR3HCAR2 | |
| SCHEMBL2784997 | 0.89 | ALDH1A1 (0.71) | ALDH1A1APPGAAHCAR3HCAR2 | |
| SCHEMBL3259196 | 0.87 | ALDH1A1 (0.69) | ALDH1A1APPGAAHCAR3HCAR2 | |
| SCHEMBL10860350 | 0.84 | ALDH1A1 (0.65) | ALDH1A1APPGAAHCAR3HCAR2 | |
| SCHEMBL6222092 | 0.84 | ALDH1A1 (0.60) | ALDH1A1APPGAAHCAR3HCAR2 | |
| SCHEMBL2690817 | 0.83 | ALDH1A1 (0.63) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL10727799 | 0.83 | ALDH1A1 (0.91) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL1433 | 0.82 | — | — | |
| Niacin SCHEMBL3081560 | 0.82 | ALDH1A1 (1.00) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL30844065 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10245330-B2 | Compositions and methods for imaging | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-04-02 | — | — | US | disclosed |
| US-20170296681-A1 | COMPOSITIONS AND METHODS FOR IMAGING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2017-10-19 | — | — | US | disclosed |
| US-20170296681-A1 | COMPOSITIONS AND METHODS FOR IMAGING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2017-10-19 | — | — | US | disclosed |
| US-9085589-B2 | Cephem derivative | SHIONOGI & CO., LTD. (JP) | 2015-07-21 | — | — | US | disclosed |
| US-9085589-B2 | Cephem derivative | SHIONOGI & CO., LTD. (JP) | 2015-07-21 | — | — | US | disclosed |
| US-20130209360-A1 | Compositions and Methods for Imaging | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-08-15 | — | — | US | disclosed |
| US-20130096299-A1 | NOVEL CEPHEM DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2013-04-18 | — | — | US | disclosed |
| US-8133909-B2 | Heteroaromatic monoamides as orexinin receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2012-03-13 | — | — | US | disclosed |
| CN-102066325-A | Heteroaromatic monoamides as orexin receptor antagonists | HOFFMANN LA ROCHE | 2011-05-18 | — | — | CN | disclosed |
| EP-2297102-A1 | HETEROAROMATIC MONOAMIDES AS OREXININ RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2011-03-23 | — | — | EP | disclosed |
| CN-101223162-A | Indolylmaleimide derivatives | NOVARTIS AG (CH) | 2008-07-16 | — | — | CN | disclosed |
| WO-2008077646-A1 | NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-07-03 | — | — | WO | disclosed |
| EP-1204657-A1 | PIPERIDINE AND PYRROLIDINE DERIVATIVES DISPLAYING NEURONAL ACTIVITY | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001012622-A1 | PIPERIDINE AND PYRROLIDINE DERIVATIVES DISPLAYING NEURONAL ACTIVITY | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-02-22 | — | — | WO | disclosed |
| EP-0173497-B1 | TETRACYCLIC SPIRO-HYDANTOIN ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1989-09-06 | — | — | EP | disclosed |
| US-4656169-A | ENZYME INHIBITORS | PFIZER INC. (US) | 1987-04-07 | — | — | US | disclosed |
| EP-0173497-A1 | Tetracyclic spiro-hydantoin aldose reductase inhibitors | PFIZER INC. (US) | 1986-03-05 | — | — | EP | disclosed |
| WO-1986001107-A1 | TETRACYCLIC SPIRO-HYDANTOIN ALDOSE REDUCTASE INHIBITORS, COMPOSITIONS AND METHODS OF MAKING | PFIZER INC. (US) | 1986-02-27 | — | — | WO | disclosed |
| US-4204044-A | SELECTIVE ASYMMETRIC, ENZYMATIC DEHYDROGENATIKN USING STREPTOMYCES, PSEUDOMONAS, BACILLUS OR CORYNEFORM MICROORGANISMS | HOFFMANN-LA ROCHE INC. (US) | 1980-05-20 | — | — | US | disclosed |
| EP-0000560-A1 | Process for the preparation of optically active alpha-hydroxycarboxylic acids | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1979-02-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10245330-B2 | Compositions and methods for imaging | GPX4, PRDX5, PRDX2 | ALDH1A1 2355/4885APP 1744/4885GAA 2239/4885 |
| US-20170296681-A1 | COMPOSITIONS AND METHODS FOR IMAGING | GPX4, PRDX5, PRDX2 | ALDH1A1 2355/4885APP 1744/4885GAA 2239/4885 |
| US-20130209360-A1 | Compositions and Methods for Imaging | GPX4, PRDX5, PRDX2 | ALDH1A1 2355/4885APP 1744/4885GAA 2239/4885 |
| US-20130096299-A1 | NOVEL CEPHEM DERIVATIVE | LBR, UBE2D3, MRPL21 | ALDH1A1 823/4885APP 4182/4885GAA 1362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.