Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 12/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | SUV39H1 | O43463 | 2/20 | 0.48 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.48 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26559399 | 0.88 | PRKDC (0.50) | PRKDCRPS6KB1SUV39H1PRMT1SMYD3 | |
| SCHEMBL21664414 | 0.84 | ENPP1 (0.48) | PRKDCRPS6KB1SUV39H1PRMT1SMYD3 | |
| SCHEMBL26559448 | 0.76 | PRKDC (0.46) | PRKDCSUV39H1PRMT1SMYD3LRRK2 | |
| SCHEMBL21664387 | 0.75 | HTT (0.55) | PRKDCRPS6KB1PDE3A | |
| SCHEMBL26230078 | 0.75 | CHRM4 (0.50) | PRKDCPDE3A | |
| SCHEMBL21456810 | 0.75 | ENPP1 (0.47) | PRKDCSUV39H1PRMT1SMYD3LRRK2 | |
| SCHEMBL26564079 | 0.74 | PRKDC (0.44) | PRKDCSUV39H1PRMT1SMYD3LRRK2 | |
| SCHEMBL21664419 | 0.74 | ENPP1 (0.49) | PRKDCSUV39H1PRMT1SMYD3PDE3A | |
| SCHEMBL21456831 | 0.72 | CCRL2 (0.47) | PRKDCPDE3A | |
| SCHEMBL4127724 | 0.71 | DOT1L (0.73) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3551188-B1 | SUBSTITUTED QUINAZOLINE SULFONAMIDES AS THIOREDOXIN INTERACTING PROTEIN (TXNIP) INHIBITORS | SOUTHERN RES INST (US) | 2023-10-18 | — | — | EP | disclosed |