Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYCR1 | P32322 | 3/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.39 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26677103 | 0.80 | PYCR1 (0.65) | PYCR1SLC6A2SLC6A4SLC6A3CYP1A2 | |
| SCHEMBL2657018 | 0.80 | SLC6A2 (0.52) | PYCR1SLC6A2SLC6A4SLC6A3CYP1A2 | |
| SCHEMBL13416729 | 0.79 | PYCR1 (0.59) | PYCR1SLC6A2SLC6A4SLC6A3TDP1 | |
| SCHEMBL2655817 | 0.79 | PYCR1 (0.54) | PYCR1SLC6A2SLC6A4SLC6A3CYP1A2 | |
| SCHEMBL16553471 | 0.77 | PYCR1 (0.61) | PYCR1SLC6A2SLC6A4SLC6A3CYP1A2 | |
| SCHEMBL4027414 | 0.77 | MEN1 (0.50) | PYCR1SLC6A2SLC6A4SLC6A3CYP1A2 | |
| SCHEMBL26675992 | 0.76 | PYCR1 (0.51) | PYCR1SLC6A2SLC6A4SLC6A3CYP1A2 | |
| Hydrochloric Acid SCHEMBL8648703 | 0.76 | PYCR1 (0.59) | PYCR1SLC6A2SLC6A4SLC6A3CYP1A2 | |
| SCHEMBL2580840 | 0.75 | PYCR1 (0.48) | PYCR1SLC6A2SLC6A4SLC6A3CYP1A2 | |
| SCHEMBL23374623 | 0.74 | PYCR1 (0.55) | PYCR1SLC6A2SLC6A4SLC6A3HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196106-B2 | Cyanothiophene derivatives, compositions containing such compounds and methods of use | MERCK & CO., INC (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196106-B2 | Cyanothiophene derivatives, compositions containing such compounds and methods of use | MERCK & CO., INC (US) | 2007-03-27 | — | — | US | disclosed |
| US-20040097552-A1 | Cyanothiophene derivatives, compositions containing such compounds and methods of use | MERCK SHARP & DOHME CORP. | 2004-05-20 | — | — | US | disclosed |
| US-20040097552-A1 | Cyanothiophene derivatives, compositions containing such compounds and methods of use | MERCK SHARP & DOHME CORP. | 2004-05-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097552-A1 | Cyanothiophene derivatives, compositions containing such compounds and methods of use | GLP1R, GPR119, GCGR | PYCR1 100/4885SLC6A2 771/4885SLC6A4 870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.