Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 14/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26559097 | 0.85 | PRKDC (0.41) | PDE3ACYP3A4PRKDC | |
| SCHEMBL26563914 | 0.85 | HTT (0.55) | PDE3AALDH1A1PRKDC | |
| SCHEMBL30562966 | 0.85 | IRAK4 (0.48) | LRRK2PDE3BPDE3APDE10AHRH4 | |
| SCHEMBL21664243 | 0.85 | IRAK4 (0.48) | LRRK2PDE3BPDE3APDE10AHRH4 | |
| SCHEMBL26551781 | 0.83 | ENPP1 (0.51) | PDE3BPDE3APDE10ACYP1A2CYP3A4 | |
| SCHEMBL26552675 | 0.83 | JAK2 (0.42) | LRRK2PDE3BPDE3APDE10AIRAK4 | |
| SCHEMBL26559069 | 0.82 | HRH4 (0.44) | PDE10AHRH4IRAK4PRKDC | |
| SCHEMBL26564090 | 0.82 | DYRK1A (0.45) | LRRK2PDE3ACYP1A2CYP3A4CLK4 | |
| SCHEMBL26553056 | 0.81 | PRKDC (0.60) | PRKDC | |
| SCHEMBL26559027 | 0.81 | ENPP1 (0.43) | PDE3APRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3551188-B1 | SUBSTITUTED QUINAZOLINE SULFONAMIDES AS THIOREDOXIN INTERACTING PROTEIN (TXNIP) INHIBITORS | SOUTHERN RES INST (US) | 2023-10-18 | — | — | EP | disclosed |