Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 8/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11655101 | 0.93 | ACHE (0.43) | ACHEKDM4EGLAEPHX1ALDH1A1 | |
| SCHEMBL27972879 | 0.93 | ACHE (0.43) | ACHEKDM4EGLAEPHX1ALDH1A1 | |
| SCHEMBL11031342 | 0.87 | — | — | |
| SCHEMBL2819850 | 0.85 | ACHE (0.47) | ACHEKDM4EGLAEPHX1ALDH1A1 | |
| SCHEMBL16824229 | 0.84 | EPHX1 (0.59) | ACHEEPHX1ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL2912153 | 0.83 | ACHE (0.48) | ACHEKDM4EGLAEPHX1ALDH1A1 | |
| SCHEMBL28700176 | 0.82 | KDM4E (0.40) | ACHEKDM4EGLAEPHX1ALDH1A1 | |
| SCHEMBL851200 | 0.81 | — | — | |
| SCHEMBL42937 | 0.81 | — | — | |
| SCHEMBL27922365 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697324-A1 | BENZOYL AMINO PYRIDYL CARBOXYLIC ACID DERIVATIVES USEFUL AS GLUCOKINASE (GLK) ACTIVATORS | AstraZeneca AB (SE) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005054200-A1 | BENZOYL AMINO PYRIDYL CARBOXYLIC ACID DERIVATIVES USEFUL AS GLUCOKINASE (GLK) ACTIVATORS | ASTRAZENECA AB (SE) | 2005-06-16 | — | — | WO | disclosed |