Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 14/20 | 0.43 |
| ▸ | GIPR | P48546 | 9/20 | 0.43 |
| ▸ | GLP1R | P43220 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 3/20 | 0.39 |
| ▸ | PPARD | Q03181 | 3/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654697 | 0.87 | GCGR (0.55) | GCGRGIPRGLP1RPPARAPPARD | |
| SCHEMBL2656365 | 0.87 | GCGR (0.40) | GCGRPPARAPPARDPPARG | |
| SCHEMBL2654628 | 0.85 | GCGR (0.43) | GCGRGIPRGLP1RPPARAPPARD | |
| SCHEMBL2655056 | 0.85 | GCGR (0.47) | GCGRGIPRGLP1RPPARAPPARD | |
| SCHEMBL2653886 | 0.81 | GCGR (0.54) | GCGRGIPREPHX2 | |
| SCHEMBL2655312 | 0.81 | GCGR (0.54) | GCGRGIPREPHX2 | |
| SCHEMBL2655054 | 0.81 | GCGR (0.54) | GCGRGIPREPHX2 | |
| SCHEMBL2656515 | 0.81 | RAB9A (0.41) | GCGRGIPRGLP1RPPARAPPARG | |
| SCHEMBL2656116 | 0.80 | GCGR (0.55) | GCGRGIPRGLP1RPPARAPPARD | |
| SCHEMBL2655617 | 0.79 | GCGR (0.61) | GCGREPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | claimed |
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |